AKT Pathway Genes Define 5 Prognostic Subgroups in Glioblastoma
نویسندگان
چکیده
منابع مشابه
AKT Pathway Genes Define 5 Prognostic Subgroups in Glioblastoma
Activity of GFR/PI3K/AKT pathway inhibitors in glioblastoma clinical trials has not been robust. We hypothesized variations in the pathway between tumors contribute to poor response. We clustered GBM based on AKT pathway genes and discovered new subtypes then characterized their clinical and molecular features. There are at least 5 GBM AKT subtypes having distinct DNA copy number alterations, e...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0100827